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This research aims to isolate and characterize subpopulations of natural killer cells using specific monoclonal antibodies.

A subset of human natural killer cells isolated and characterized by monoclonal antibodies

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This research aims to isolate and characterize subpopulations of natural killer cells using specific monoclonal antibodies.
Monoclonal antibodies were induced against leukemic T cells from a chronic lymphocytic leukemia patient.
Indirect immunofluorescence was utilized to identify sub-populations of mononuclear blood cells.
Cell subsets were defined based on their expression of the T811 and M522 antigens.
Antibody T811 defines a surface antigen restricted to a subset of T cells.
The total NK activity of nonadherent peripheral blood leukocytes is associated with the M522-defined antigen, found in 9-17% of cells.
Approximately 4% of nonadherent leukocytes express both T811 and M522 antigens, isolated to over 85% purity.

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Randomized trial identifies natural killer cell subsets via monoclonal antibodies, highlighting their specific markers.

Lohmeyer et al. (1981) studied this question.

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