Key result
Platelets play relevant functions in inflammation, with thrombosis and inflammation sharing several key molecular mechanisms as intrinsically linked processes.
This review highlights the intrinsically linked molecular mechanisms between thrombosis and inflammation mediated by platelets.
May guide combined antithrombotic-anti-inflammatory strategies; leaves open prospective validation in clinical cohorts.
For many years it has been known that platelets play an important role in thrombosis and hemostasis. In recent times, however, it has become evident that platelets also have relevant functions in inflammation. It was shown that thrombosis and inflammation share several key molecular mechanisms and in fact are 2 intrinsically linked processes. In this review, we intend to give a short overview with emphasis on work stemming from our laboratory.
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Wagner et al. (2003) conducted a review in Thrombosis and inflammation. Platelets play relevant functions in inflammation, with thrombosis and inflammation sharing several key molecular mechanisms as intrinsically linked processes.
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