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January 1, 1993Proceedings of the National Academy of SciencesOpen Access

Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.

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Authors

JBJames D. BergstromCarestream (United States)MKMarc M. KurtzInstitute for In Vitro SciencesDRDeborah J. RewMerck & Co., Inc., Rahway, NJ, USA (United States)

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Bergstrom et al. (1993) studied this question.

synapsesocial.com/papers/6a1c65cfecffbcc5fca14824https://doi.org/10.1073/pnas.90.1.80
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The squalestatings, novel inhibitors of squalene synthase produced by a species of Phoma. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activity.1992 · 183 citations
  2. 2Isoprenoid (phosphinylmethyl)phosphonates as inhibitors of squalene synthetase1988 · 85 citations
  3. 3ChemInform Abstract: Isoprenyl Phosphinylformates: New Inhibitors of Squalene Synthetase.1991 · 5 citations
  4. 4Molecular cloning and characterization of the yeast gene for squalene synthetase.1991 · 173 citations
  5. 5Studies on the Mechanism of Squalene Biosynthesis1970 · 97 citations