Key result
Isolated moderate to severe tricuspid regurgitation significantly increased the 3-year risk of all-cause death and major adverse cardiac events compared to no moderate to severe TR (HR 2.86).
Why the study?
Does isolated moderate to severe tricuspid regurgitation increase the risk of all-cause death and major adverse cardiac events in patients with preserved LVEF?
Cohort (n=3,714)
No
Does isolated moderate to severe tricuspid regurgitation increase the risk of all-cause death and major adverse cardiac events in patients with preserved LVEF?
Effect estimate: HR 2.86 (95% CI 1.37-6.37)
Absolute Event Rate: 61.5% vs 24.3%
p-value: p=0.043
Isolated moderate to severe tricuspid regurgitation is independently associated with a significantly higher risk of all-cause death and major adverse cardiac events in patients with preserved LVEF.
Supports monitoring in preserved LVEF; leaves open whether TR intervention improves outcomes.
Background:The aim of this study was to evaluate the association of isolated tricuspid regurgitation (TR) with long-term outcome in patients with preserved left ventricular ejection fraction (LVEF).
No takes yet. Share an insight, caveat, or question.
Seko et al. (2019) conducted a cohort in Isolated Tricuspid Regurgitation with Preserved Ejection Fraction (n=3,714). Moderate to severe tricuspid regurgitation vs. No moderate to severe tricuspid regurgitation was evaluated on Composite of all-cause death and major adverse cardiac events (MACE) (HR 2.86, 95% CI 1.37-6.37, p=0.043). Isolated moderate to severe tricuspid regurgitation significantly increased the 3-year risk of all-cause death and major adverse cardiac events compared to no moderate to severe TR (HR 2.86).
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: