Key result
Higher estradiol levels were associated with higher right ventricular ejection fraction (beta 0.88) in women using hormone therapy, while higher androgens were associated with greater right ventricular mass and volumes in both sexes.
Why the study?
Are sex hormone levels associated with right ventricular structure and function in individuals free of cardiovascular disease?
Cross-Sectional (n=3,695)
Yes
Are sex hormone levels associated with right ventricular structure and function in individuals free of cardiovascular disease?
Effect estimate: beta 0.88 (95% CI 0.32 to 1.43)
p-value: p=0.002
Sex hormones, particularly estradiol and androgens, are significantly associated with right ventricular structure and systolic function in individuals without cardiovascular disease.
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Should not yet inform clinical RV assessment; leaves open causal roles of sex hormones in RV remodeling.
Ventetuolo et al. (2010) conducted a cross-sectional in Free of clinical cardiovascular disease (n=3,695). Serum sex hormones (Estradiol, Testosterone, DHEA, SHBG) was evaluated on Right ventricular ejection fraction (RVEF) associated with estradiol in women using hormone therapy (beta 0.88, 95% CI 0.32 to 1.43, p=0.002). Higher estradiol levels were associated with higher right ventricular ejection fraction (beta 0.88) in women using hormone therapy, while higher androgens were associated with greater right ventricular mass and volumes in both sexes.
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