Synthesis and biological studies on ovarian cancer cells of new heterocyclic molecules inspired by MIM1, an inhibitor of the anti-apoptotic protein Mcl-1

Q: What does this research mean for the field?

Novel heterocyclic molecules inspired by the Mcl-1 inhibitor MIM1 can be synthesized and exhibit biological activity against ovarian cancer cells. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Jocelyn Pezeril; Louis‐Bastien Weiswald; Ali Soulieman; Hippolyte Paysant; Ali Hachem; Émilie Brotin; Christophe Denoyelle; Anne Sophie Voisin‐Chiret; Nicolas Gouault; René Grée; Nicolas Levoin; Laurent Poulain

doi:10.1039/d5nj00175g

January 1, 2025New Journal of ChemistryOpen Access

Synthesis and biological studies on ovarian cancer cells of new heterocyclic molecules inspired by MIM1, an inhibitor of the anti-apoptotic protein Mcl-1

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Abstract

Research on new and potent inhibitors of anti-apoptotic proteins is a very active and promising topic in bioorganic and medicinal chemistry.

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Pezeril et al. (2025) studied this question.

synapsesocial.com/papers/6a1c6b371e0790f17da14df2 https://doi.org/10.1039/d5nj00175g

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Synthesis and biological studies on ovarian cancer cells of new heterocyclic molecules inspired by MIM1, an inhibitor of the anti-apoptotic protein Mcl-1

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Synthesis and biological studies on ovarian cancer cells of new heterocyclic molecules inspired by MIM1, an inhibitor of the anti-apoptotic protein Mcl-1

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Abstract

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