What question did this study set out to answer?

This research aims to identify and characterize biochemical properties of sodium channel alpha subunits across different excitable tissues.

September 6, 1988Biochemistry

Biochemical properties of sodium channels in a wide range of excitable tissues studied with site-directed antibodies

View Full Paper

Ask AI

Bookmark

This research aims to identify and characterize biochemical properties of sodium channel alpha subunits across different excitable tissues.
Utilized site-directed antibodies against a specific peptide to bind sodium channel alpha subunits in various tissues.
Examined binding affinity of antibodies in rat and eel brain, rat skeletal muscle, rat heart, eel electroplax, and locust nervous system.
Assessed posttranslational modifications via neuraminidase treatment and analyzed phosphorylation by cAMP-dependent protein kinase.
Identified sodium channel alpha subunits in rat heart and locust brain and nerve cord for the first time.
Demonstrated that alpha subunits from various tissues have different subunit associations and posttranslational modifications.
Observed varying effects of neuraminidase treatment on molecular weight across different tissues, ranging from 4000 to 58000.

No takes yet. Share an insight, caveat, or question.

Randomized trial examines sodium channel properties in various tissues, indicating unique modifications and associations.

Gordon et al. (1988) studied this question.

View Full Paper

Ask AI

Bookmark