What does this research mean for the field?

Human cardiac hypertrophy is characterized by a significant shift in myosin heavy chain isoform expression, specifically the disappearance of the alpha chain in pressure-overloaded ventricles and an increase of the beta chain up to 90% in hypertrophied atria. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

December 2, 1984European Heart Journal

Myosin changes in hypertrophied human atrial and ventricular myocardium. A correlated immuno-fluorescence and quantitative immunochemical study on serial cryosections

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Authors

SSStefano SchiaffinoGeneral Cardiology LGLuisa GorzaHôpital Foch LSL SagginUniversity of Padua

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Implication

Chamber-specific α/β myosin heavy chain expression occurs in human hearts; extends animal data but leaves open functional roles in hypertrophy.

Key Points

Key points are not available for this paper at this time.

Cite This Study

Schiaffino et al. (1984) studied this question.

synapsesocial.com/papers/6a1c6eef973ffece4bc3cf9e https://doi.org/10.1093/eurheartj/5.suppl_f.95

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Implication

Chamber-specific α/β myosin heavy chain expression occurs in human hearts; extends animal data but leaves open functional roles in hypertrophy.

Myosin changes in hypertrophied human atrial and ventricular myocardium. A correlated immuno-fluorescence and quantitative immunochemical study on serial cryosections

Discussion

Member takes

Implication

Key Points

Cite This Study

Myosin changes in hypertrophied human atrial and ventricular myocardium. A correlated immuno-fluorescence and quantitative immunochemical study on serial cryosections

Discussion

Member takes

Implication

Key Points

Cite This Study

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