Key result
Cognitive interventions significantly improved global cognition compared to control interventions in individuals with Alzheimer's disease (Hedges' g 0.43), with combined interventions being the most effective.
Why the study?
The effectiveness of cognitive interventions varies greatly among studies in Alzheimer's disease, necessitating a more comprehensive evaluation of their effects.
Do cognitive interventions improve global cognition in individuals with Alzheimer's disease?
Population
Individuals with possible or probable Alzheimer's disease across randomized controlled trials
Comparison
Cognitive interventions (CT, CS, CR, and combined) vs control interventions
Design
Systematic review and network meta-analysis of randomized controlled trials
Authors
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Supports integrating cognitive interventions into Alzheimer’s care; confirms combined approaches as most effective via network meta-analysis of RCTs.
Meta-Analysis (n=2,179)
Do cognitive interventions improve global cognition in individuals with Alzheimer's disease?
Effect estimate: Hedges' g 0.43 (95% CI 0.28 to 0.58)
p-value: p=<0.01
Cognitive interventions, particularly combined interventions and cognitive training, significantly improve global cognition and specific cognitive domains in individuals with Alzheimer's disease.
Xiang et al. (2023) conducted a meta-analysis in Alzheimer's disease (n=2,179). Cognitive interventions (cognitive training, stimulation, rehabilitation, and combined) vs. Control interventions (active or passive) was evaluated on Change in global cognition (MMSE) (Hedges' g 0.43, 95% CI 0.28 to 0.58, p=<0.01). Cognitive interventions significantly improved global cognition compared to control interventions in individuals with Alzheimer's disease (Hedges' g 0.43), with combined interventions being the most effective.
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