Cytogenetic analysis demonstrates widespread constitutive heterochromatin polymorphism in humans, indicating a high frequency of chromosomal structural variation across populations.
Genetic polymorphism has been demonstrated in man for many characteristics including blood groups, serum proteins, tissue enzymes, and hemoglobins. A class of chromosomal polymorphism involving constitutive heterochromatin has now been found. Through the use of a special technique that permits visualization of heterochromatin, seven heterochromatin variants have been found among four individuals. These results suggest a very high frequency of variability of heterochromatin in the population.
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Craig-Holmes et al. (1971) studied this question.
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