Why the study?
Following therapeutic potential in experimental acute myocarditis, the diagnostic relevance of serum S100A8/S100A9 levels in suspected acute and chronic myocarditis and heart failure without inflammation needed investigation.
Does serum S100A8/A9 level measurement accurately diagnose recent onset myocarditis in patients with suspected acute myocarditis?
Population
32 recent onset myocarditis, 112 DCM with inflammation, 58 DCM without inflammation, and 25 controls
Comparison
Recent onset myocarditis vs DCM with/without inflammation vs controls
Design
Observational study
Follow-up
Mean 8.5 months in a subgroup of 12 patients
Key result
Serum S100A8/A9 levels were significantly elevated in recent-onset myocarditis versus controls (1948 vs 426 ng/mL; P<0.0001), providing a diagnostic accuracy of 0.949 (95% CI 0.89-1).
Authors
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May support S100A8/A9 as diagnostic biomarker in suspected recent-onset myocarditis; leaves open prospective validation before clinical adoption.
Observational (n=227)
Does serum S100A8/A9 level measurement accurately diagnose recent onset myocarditis in patients with suspected acute myocarditis?
Effect estimate: Accuracy 0.949 (95% CI 0.89-1)
p-value: p=<0.0001
Serum S100A8/A9 is a highly accurate biomarker for diagnosing recent onset acute myocarditis and correlates with disease activity and cardiac inflammation.
Müller et al. (2020) conducted an observational in Myocarditis and dilated cardiomyopathy (n=227). Serum S100A8/A9 levels vs. Controls and dilated cardiomyopathy without inflammation was evaluated on Diagnostic accuracy of serum S100A8/A9 levels (cut-off 583 ng/mL) (Accuracy 0.949, 95% CI 0.89-1, p=<0.0001). Serum S100A8/A9 levels were significantly elevated in recent-onset myocarditis versus controls (1948 vs 426 ng/mL; P<0.0001), providing a diagnostic accuracy of 0.949 (95% CI 0.89-1).
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