Pathobiology of pulmonary arterial hypertension and right ventricular failure
Key result
Recent pathobiological concepts of pulmonary arterial hypertension and right ventricular failure highlight the shift from classical mechanical concepts to cell injury and repair mechanisms.
Population
Patients with pulmonary arterial hypertension (PAH) and right ventricular failure
Design
Review
Authors
Discussion
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Member takes
Implication
Should not change PAH management; leaves open whether cell-repair targets will improve outcomes in trials.
Structured PICO
P
Population
Patients with pulmonary arterial hypertension (PAH) and right ventricular failure
This review highlights the evolving understanding of PAH pathobiology, emphasizing the shift from purely mechanical concepts to complex cellular interactions, which is critical for designing new therapies.
Cite This Study
Voelkel et al. (2012) conducted a review in Pulmonary arterial hypertension and right ventricular failure. Recent pathobiological concepts of pulmonary arterial hypertension and right ventricular failure highlight the shift from classical mechanical concepts to cell injury and repair mechanisms.