Experimental imaging demonstrates nanometer-scale surface topography and membrane fluctuations in living cells, suggesting a label-free approach for tracking subtle cellular dynamics.
We have developed a Linnik-type interference microscope provided with a low-coherent light source to obtain topographic images of an intact cellular membrane on a nanometer scale. Our technique is based on measurement of the interference between light reflected from the cell surface and a reference beam. The results show full field surface topography of cultured cells and reveal an intrinsic membrane motion of tens of nanometers.
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Yamauchi et al. (2008) studied this question.
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