Key result
Pulsed field ablation for atrial fibrillation demonstrated high efficacy and safety, with a 100% successful pulmonary vein isolation rate, 1.78% arrhythmia recurrence, and a 2.23% complication rate.
Why the study?
Although early results for pulsed field ablation as an alternative to other catheter ablation energy sources are encouraging, secondary data about outcomes are lacking.
Does pulsed field ablation improve efficacy and safety in adults with atrial fibrillation?
Meta-Analysis (n=485)
Does pulsed field ablation improve efficacy and safety in adults with atrial fibrillation?
Pulsed-field ablation appears to be a highly effective and safe novel modality for atrial fibrillation, achieving 100% pulmonary vein isolation with low rates of recurrence and complications in early observational data.
May support PFA for AF ablation; leaves open confirmation versus thermal ablation in randomized trials.
Background and Aim Pulse field ablation (PFA) has emerged as a safe alternative to other catheter ablation energy sources for patients. Although early results are encouraging, secondary data about outcomes are lacking. Herein, we aimed to assess the safety and efficacy of the novel technique. Methods We searched PubMed, Ovid, Google Scholar, Web of Science, and Scopus databases and several major scientific conferences for studies reporting results regarding PFA. Results Sixteen studies were included, reporting 485 patients with atrial fibrillation who underwent pulsed field operations. Patients averaged 60 years of age. The total duration of the procedure is 94 min. The average Fluoro procedure takes 17 min. Isolation of all pulmonary veins was 100% with a 95% confidence interval (CI) ( p > 0.05). Overall, the recurrence rate of arrhythmia in the participants was 2.84% (95% CI) ( p > 0.05). Complications were detected during or after the PFA procedure at a rate of 2.23% ( p < 0.05), with 95% CI indicating the high safety of the PFA procedure Conclusion Using pulsed‐field ablation as a new treatment for atrial fibrillation has proven safe and effective.
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Shaheen et al. (2023) conducted a meta-analysis in Atrial fibrillation (n=485). Pulsed field ablation (PFA) was evaluated on Successful pulmonary vein isolation (PVI) (95% CI 0.0000-1.0000, p=1.00). Pulsed field ablation for atrial fibrillation demonstrated high efficacy and safety, with a 100% successful pulmonary vein isolation rate, 1.78% arrhythmia recurrence, and a 2.23% complication rate.
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