Key result
Pregnancy in rats increased the intensity of renal immunocytochemical staining for angiotensin-(1-7) by 56% and ACE2 by 117% compared to virgin rats (P<0.05).
Why the study?
Does pregnancy increase the renal immunocytochemical expression of ANG-(1-7) and ACE2 in Sprague-Dawley rats?
Does pregnancy increase the renal immunocytochemical expression of ANG-(1-7) and ACE2 in Sprague-Dawley rats?
Effect estimate: 56% and 117% increase
p-value: p=<0.05
Pregnancy increases renal immunocytochemical expression of angiotensin-(1-7) and ACE2 in rats, suggesting ACE2 may contribute to local ANG-(1-7) production during pregnancy.
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Hypothesis-generating in rodent models; leaves open translation to human pregnancy and clinical relevance.
Brosnihan et al. (2003) studied Pregnancy. Pregnancy vs. Virgin rats was evaluated on Quantification of angiotensin-(1-7) and ACE2 immunocytochemical staining (56% and 117% increase, p=<0.05). Pregnancy in rats increased the intensity of renal immunocytochemical staining for angiotensin-(1-7) by 56% and ACE2 by 117% compared to virgin rats (P<0.05).
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