Dennis Slone, Leonard F. Gaetano, Leslie Lipworth, Samuel Shapiro, George Parker Lewis, Hershel Jick, Computer Analysis of Epidemiologic Data on Effect of Drugs on Hospital Patients, Public Health Reports (1896-1970), Vol. 84, No. 1 (Jan., 1969), pp. 39-52
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Slone et al. (1969) studied this question.
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