Association between osteoarthritis and cardiovascular disease: Systematic review and meta-analysis
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Key result
Osteoarthritis is linked to a ~38% prevalence of cardiovascular disease.
- 95% CI 37.2 to 39.6
- n=32,278,744
Why the study?
Is osteoarthritis associated with an increased risk of cardiovascular disease compared with non-osteoarthritis cohorts?
Population
32,278,744 individuals from 15 studies (cohort, case-control, randomised and non-randomised controlled trials)
Comparison
Osteoarthritis (exposure) vs Matched non-osteoarthritis cohorts
Design
Meta-analysis
Authors
Discussion
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Implication
May warrant cardiovascular risk assessment in osteoarthritis; leaves open causal mechanisms and intervention effects.
Study Design
Type
Meta-Analysis (n=32,278,744)
Structured PICO
Is osteoarthritis associated with an increased risk of cardiovascular disease compared with non-osteoarthritis cohorts?
P
Population
32,278,744 individuals from 15 studies assessing the prevalence and risk of cardiovascular disease in patients with osteoarthritis compared to non-osteoarthritis controls.
E
Exposure
Osteoarthritis (exposure)
C
Comparator
Matched non-osteoarthritis cohorts
O
Outcome
Prevalence of cardiovascular disease pathologyhard clinical
Osteoarthritis is associated with a significantly increased prevalence of cardiovascular disease, particularly heart failure and ischaemic heart disease, highlighting the need to understand shared pathophysiological mechanisms.
Limitations
- Four included studies were cross-sectional, limiting the ability to deduce directionality of variables with certainty.
- Longitudinal studies had relatively short follow-up periods.
- A large proportion of studies relied upon medical and/or prescription records to ascertain CVD status, which may underestimate cardiovascular risk factors.
- Unable to determine whether worse CVD outcomes in osteoarthritis patients are due to an adverse risk factor profile, use of medications like NSAIDs, or shared pathophysiological mechanisms.
- Not possible to analyze the association between baseline cardiovascular risk scores and the occurrence of cardiovascular events.
Cite This Study
Hall et al. (2015) conducted a meta-analysis in Osteoarthritis (n=32,278,744). Osteoarthritis vs. Non-osteoarthritis cohorts was evaluated on Point prevalence of any cardiovascular disease events (95% CI 37.2 to 39.6). Osteoarthritis was associated with a 38.4% pooled prevalence of cardiovascular disease and an increased risk of incident heart failure (RR 2.80) and ischaemic heart disease (RR 1.78) compared to matched controls.
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