Key result
Sex differences in the distribution of premature ventricular contraction profiles were not statistically significant (P=0.167), although fast heart rate-related PVCs were most common in males.
Why the study?
To investigate the correlation between premature ventricular contraction frequency and heart rate in Chinese adults, emphasizing sex-specific differences in clinical characteristics.
Does the correlation between premature ventricular contraction frequency and heart rate differ by sex in Chinese adults?
Cross-Sectional (n=478)
No
Does the correlation between premature ventricular contraction frequency and heart rate differ by sex in Chinese adults?
p-value: p=0.167
Although not statistically significant, there is a trend toward sex-specific differences in the correlation between PVC frequency and heart rate, with males more likely to have fast heart rate-related PVCs and females more likely to have independent heart rate-related PVCs.
Non-significant sex differences in PVC profiles should not change practice; leaves open sex-specific patterns for larger prospective studies.
Objective: To investigate the correlation between premature ventricular contraction (PVC) frequency and heart rate (HR) in Chinese adults, with an emphasis on sex-specific differences in clinical characteristics. Patients and Methods: This retrospective study analyzed 24-hour Holter monitoring data from 478 inpatients at the First People's Hospital of Yibin between January 2021 and December 2022. The inclusion criteria were age ≥18 years, ≥20 hours of Holter recording, frequent PVCs (≥ 500 PVCs), and complete clinical profiles. Patients were stratified into three groups on the basis of the hourly correlation between PVC counts and HR: fast heart rate-related PVC (F-HR-PVC), slow heart rate-related PVC (S-HR-PVC), and independent heart rate-related PVC (I-HR-PVC). Heart rate variability (HRV) indices were assessed to evaluate autonomic nervous system activity. Results: Among the 478 patients, 267 were males and 211 were females with a mean age of 65.7±13.0 years. The mean PVC burden was 5.7±7.0%, and the mean left ventricular ejection fraction (LVEF) was 59.1±8.7%. In males, the F-HR-PVC group was most common (45.3%), while in females, the I-HR-PVC group was most prevalent (50.2%). Despite these observed differences, a chi-square test did not reveal statistically significant differences in the distribution of VPC profiles between sexes (P=0.167). Analysis of clinical characteristics and Holter indices across sex groups showed significant differences in males, particularly in age, maximum heart rate, and minimum heart rate (P < 0.05). In females, significant intergroup differences were observed in VPC burden (P < 0.05). Conclusion: Although no significant sex differences were observed in the correlation between PVC frequency and HR, the study suggests a potential gender influence on VPC characteristics. These findings may inform future research and have implications for the development of sex-specific diagnostic and therapeutic strategies for PVCs.
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Li et al. (2025) conducted a cross-sectional in Premature ventricular contractions (n=478). Sex differences in the distribution of premature ventricular contraction profiles were not statistically significant (P=0.167), although fast heart rate-related PVCs were most common in males.
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