What question did this study set out to answer?

To evaluate tissue plasminogen activator-mediated thrombolysis in a cerebral emboli model and identify factors predisposing subjects to post-treatment hemorrhage.

May 1, 1989Neurology

Tissue plasminogen activator‐mediated thrombolysis of cerebral emboli and its effect on hemorrhagic infarction in rabbits

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Authors

PLPatrick D. LydenUniversity of Southern California JZJustin A. ZivinUniversity of California, San Diego WCWilliam ClarkEast Tennessee State University

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Implication

Animal study demonstrates tPA lyses cerebral emboli without increasing hemorrhage in rabbits, indicating stroke severity drives bleeding.

Key Points

To evaluate tissue plasminogen activator-mediated thrombolysis in a cerebral emboli model and identify factors predisposing subjects to post-treatment hemorrhage.
Injected blood clot emboli into the internal carotid arteries of rabbits, confirming 100% middle cerebral artery or internal carotid artery occlusion via angiograms.
Administered 30-minute infusions of tPA or saline vehicle control at various intervals following embolization and measured blood coagulation profiles.
tPA successfully induced thrombolysis of cerebral emboli without increasing the incidence of cerebral hemorrhage compared to saline controls across all infusion times.
tPA significantly prolonged prothrombin time and thrombin time without altering partial thromboplastin time, but these coagulation changes did not correlate with hemorrhage.
A significant positive association was observed between the severity of the initial stroke and the development of cerebral hemorrhage.

Cite This Study

Lyden et al. (1989) studied this question.

synapsesocial.com/papers/6a1c7ec166d062ff2dc3e155 https://doi.org/10.1212/wnl.39.5.703

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Tissue plasminogen activator‐mediated thrombolysis of cerebral emboli and its effect on hemorrhagic infarction in rabbits

Discussion

Member takes

Implication

Key Points

Cite This Study

Tissue plasminogen activator‐mediated thrombolysis of cerebral emboli and its effect on hemorrhagic infarction in rabbits

Discussion

Member takes

Implication

Key Points

Cite This Study

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