What does this research mean for the field?

The arrhythmogenic oscillatory inward current (ITI) in cardiac Purkinje fibres persists in the absence of electrogenic sodium-calcium exchange and arises from a channel permeable to both potassium and calcium. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1986The Journal of PhysiologyOpen Access

The arrhythmogenic current ITI in the absence of electrogenic sodium‐calcium exchange in sheep cardiac Purkinje fibres.

View Full Paper

Ask AI

Bookmark

Population

Sheep cardiac Purkinje fibres

Design

Preclinical

Authors

MCMark B. CannellElectrophysiology WLW. Jonathan LedererElectrophysiology

Discussion

Member takes

Implication

Questions NCX exclusivity in calcium-triggered arrhythmias; leaves open non-specific cation channel identification in mammalian models.

Structured PICO

Population

Sheep cardiac Purkinje fibres

Intervention

Replacement of external sodium with isotonic CaCl2 solution under conditions of 0 mM external potassium

Outcome

Characteristics of the arrhythmogenic oscillatory inward current (ITI) and after-contractionssurrogate

The arrhythmogenic current ITI in sheep Purkinje fibres is likely mediated by a non-specific cation channel permeable to potassium and calcium, rather than solely by electrogenic sodium-calcium exchange.

Cite This Study

Cannell et al. (1986) studied this question.

synapsesocial.com/papers/6a1c824f0e2acd31eb2fd3f6 https://doi.org/10.1113/jphysiol.1986.sp016075

View Full Paper

Ask AI

Bookmark

The arrhythmogenic current ITI in the absence of electrogenic sodium‐calcium exchange in sheep cardiac Purkinje fibres.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The arrhythmogenic current ITI in the absence of electrogenic sodium‐calcium exchange in sheep cardiac Purkinje fibres.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider