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July 7, 1998Circulation

Requisite Role of Cardiac Myocytes in Coronary α1-Adrenergic Constriction

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Population

Isolated coronary arterioles and cardiac myocytes

Comparison

Supernatant obtained from phenylephrine-treated… vs Direct administration of phenylephrine to…

Design

Preclinical

Authors

CTChristiane TiefenbacherMarien Hospital WeselDDDavid V. DeFilyTexas A&M Health Science CenterWCWilliam M. ChilianHeart Failure & Transplant

Discussion

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Implication

Myocyte-derived factors may mediate alpha-adrenergic coronary constriction; extends in vitro models but leaves open human translation.

Structured PICO

P
Population
Isolated coronary arterioles and cardiac myocytes
I
Intervention
Supernatant obtained from phenylephrine-treated cardiac myocytes
C
Comparator
Direct administration of phenylephrine to isolated coronary arterioles
O
Outcome
Constriction of coronary arteriolessurrogate

Cardiac myocytes play a requisite role in alpha1-adrenergic coronary arteriolar constriction via the release of myocyte-derived contractile factors such as endothelin-1.

Cite This Study

Tiefenbacher et al. (1998) studied this question.

synapsesocial.com/papers/6a1c837594dbf6307b2fdcdfhttps://doi.org/10.1161/01.cir.98.1.9
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adrenergic coronary tone during submaximal exercise in the dog is produced by circulating catecholamines. Evidence for adrenergic denervation supersensitivity in the myocardium but not in coronary vessels.1986 · 72 citations
  2. 2Sympathetic Control of Coronary Circulation1967 · 209 citations
  3. 3The Effect of Norepinephrine on the Coronary Microcirculation2008 · 39 citations
  4. 4α1 and α2-Adrenoceptor-Mediated Vasoconstriction of Large and Small Canine Coronary Arteries In Vivo1984 · 166 citations