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BACKGROUND AND OBJECTIVES: F-FP-CIT) PET, we investigated the role of brain perfusion in motor symptoms and disease progression, independent of striatal dopamine depletion. METHODS: -PP), the main region of dopamine deficit. Subsequently, we investigated the association of the SR with baseline and longitudinal motor symptoms and brain atrophy. RESULTS: = 0.017) and a decrease in brain volume. DISCUSSION: These results suggest that aberrant relative brain hyperperfusion, independent of striatal dopamine depletion, was associated with baseline and longitudinal motor deficits and progression of neurodegeneration in PD.
Yoo et al. (Wed,) studied this question.