Key result
A review of clinical and experimental studies suggests that while Torsades de Pointes is triggered by early afterdepolarizations, reentrant mechanisms likely play a role in its maintenance.
This review highlights the complex mechanisms underlying Torsades de Pointes, emphasizing the interplay between early afterdepolarizations as triggers and reentrant circuits in its maintenance.
May inform reentry-targeted TdP therapies; leaves open prospective validation before clinical adoption.
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Yuji Murakawa (2011) conducted a review in Torsades de Pointes. A review of clinical and experimental studies suggests that while Torsades de Pointes is triggered by early afterdepolarizations, reentrant mechanisms likely play a role in its maintenance.
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