Key result
A review of studies investigating Torsades de pointes suggests that while it is triggered by early afterdepolarizations, reentrant mechanisms likely play a role in its maintenance.
This review discusses the mechanisms of Torsades de Pointes, exploring the roles of early afterdepolarizations and reentry in its initiation and maintenance.
Reentry may sustain TdP after EAD initiation; leaves open precise mechanisms and targeted therapies.
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Yuji Murakawa (2011) conducted a review in Torsades de pointes. A review of studies investigating Torsades de pointes suggests that while it is triggered by early afterdepolarizations, reentrant mechanisms likely play a role in its maintenance.
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