What does this research mean for the field?

The ultrastructure of mammalian cardiac muscle is fundamentally similar to striated skeletal muscle, featuring interdigitating thick and thin filaments, while deep sarcolemma invaginations likely explain the branching appearance of cardiac fibers. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

February 1, 1961The Journal of Cell BiologyOpen Access

The Ultrastructure of Mammalian Cardiac Muscle

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Population

Papillary muscles of rat and dog hearts

Design

Preclinical

Authors

RSRichard J. StengerMount Sinai Beth Israel DSDavid SpiroNational Institutes of Health

Discussion

Member takes

Implication

Does not alter clinical practice; extends skeletal muscle filament observations to mammalian cardiac ultrastructure in preclinical models.

Structured PICO

Population

Papillary muscles of rat and dog hearts

Intervention

Fixation, embedding in araldite or methacrylate, and staining for ultrastructural examination

Outcome

Ultrastructural characteristics of mammalian cardiac muscle

This foundational preclinical study details the ultrastructure of mammalian cardiac muscle, highlighting its similarities to skeletal muscle and describing key cellular components.

Cite This Study

Stenger et al. (1961) studied this question.

synapsesocial.com/papers/6a1c85c72cc291e7bf2fe7cd https://doi.org/10.1083/jcb.9.2.325

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Implication

Does not alter clinical practice; extends skeletal muscle filament observations to mammalian cardiac ultrastructure in preclinical models.

The Ultrastructure of Mammalian Cardiac Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Ultrastructure of Mammalian Cardiac Muscle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider