Key result
Review highlights multimodal prevention and emerging therapies to reduce postthrombotic syndrome burden.
Why the study?
Despite anticoagulation and compression therapy, post thrombotic syndrome frequently complicates deep venous thrombosis, requiring improved diagnosis, risk stratification, and preventive and therapeutic modalities.
This review highlights that while anticoagulation and compression remain the cornerstone of PTS prevention, incomplete efficacy necessitates ongoing research into targeted anti-inflammatory and interventional thrombus removal therapies.
Standard anticoagulation and compression remain essential for PTS prevention; leaves open the efficacy of emerging anti-inflammatory and interventional approaches pending prospective trials.
Post thrombotic syndrome (PTS) is a frequent complication occurring in patients with deep venous thrombosis (DVT). This chronic condition is associated with a negative impact on quality of life and substantial economic costs. Despite current treatment with anticoagulants and compression therapy, a significant proportion of DVT patients develop PTS. Optimising the diagnosis and identification of high-risk patients is important to provide more appropriate individualised treatment. In addition, a better understanding of the pathogenesis is leading to the necessary improvement of both current treatment strategies and the development of new treatment modalities. Treatments aimed at prevention as well as those aimed at reducing the symptoms of already manifested PTS should be further investigated. Research is currently taking place on promising therapeutical targets including pharmacological (anti-inflammatory and venoactive drugs), and interventional approaches (e.g. mechanical thrombectomy) in patients at different stages of PTS. Progress in all these areas is needed to solve the complex problem of PTS.
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Hupperetz et al. (2024) conducted a review in Deep Venous Thrombosis (DVT) and Postthrombotic Syndrome (PTS). Postthrombotic syndrome management strategies (anticoagulants, compression therapy, endovascular interventions) was evaluated. This narrative review highlights the pathophysiology, diagnosis, and multimodal management of postthrombotic syndrome, emphasizing standard preventive measures alongside emerging interventional and pharmacological therapies.
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