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This research aims to understand how genetic factors influence spatiotemporal variations in cortical thickness during youth.

October 10, 2024Communications BiologyOpen Access

The genetics of spatiotemporal variation in cortical thickness in youth

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Randomized trial explores genetic factors in cortical thickness variation during youth, indicating vital neurodevelopmental insights.

This research aims to understand how genetic factors influence spatiotemporal variations in cortical thickness during youth.
Examined 308 MRI-derived regional cortical thickness measures in a longitudinal sample of 677 twins and family members.
Identified three neurodevelopmental epochs of genetically-mediated maturational coupling, particularly around eleven years of age.
Analyzed genetic expression data related to co-expression patterns from the Allen Human Brain Atlas.
Dynamic inter-regional genetic covariation was found in youth, with a significant increase in network strength (empirical p-value <0.0001).
Identified genes enriched for potassium transport and dendrite formation associated with structural covariation in children.
Cortical thickness covariance correlated with expression patterns of genes in neuronal cells.

Schmitt et al. (2024) studied this question.

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