Key result
Bariatric surgery significantly reduced left ventricular mass index from 43.7 to 37.8 g/m2.7 and decreased 10-year ASCVD risk from 3.7% to 0.2% in Chinese patients with obesity.
Why the study?
Very few studies have examined the effect of bariatric surgery on cardiac function, cardiac structure, and ASCVD risk in the Chinese population.
Does bariatric surgery improve echocardiographic cardiac function and reduce estimated ASCVD risk in Chinese patients with obesity?
Cohort (n=143)
No
Does bariatric surgery improve echocardiographic cardiac function and reduce estimated ASCVD risk in Chinese patients with obesity?
Absolute Event Rate: 37.8% vs 43.7%
p-value: p=<0.001
Bariatric surgery in Chinese patients with obesity is associated with significant favorable reverse cardiac remodeling and a reduction in estimated 10-year and lifetime ASCVD risk.
Background Obesity contributes to cardiac dysfunction and has an impact on arteriosclerotic cardiovascular disease (ASCVD). Weight loss after bariatric surgery (BS) may not only influence cardiac function, but also ASCVD risk. Very few studies considered the Chinese population. The primary objective was to examine the effect of surgical weight reduction on cardiac function and structure in Chinese subjects with obesity. The secondary objectives was to evaluate the impact of BS on ASCVD risk, employing the Prediction for ASCVD Risk in China (China-PAR) equation. Methods A single-center retrospective analysis of 143 patients with obesity were included in the analysis. According to the follow-up time, the enrolled patients were divided into three groups: < 12 months were defined as T1 group (n = 52); 12–24 months was defined as T2 group (n = 53); > 24 months was defined as T3 group (n = 38). The effects of BS on the cardiac function were evaluated by analyzing the echocardiographic parameters. The China-PAR equation was used to calculate ASCVD risk. Assessed the differences in variables before and after surgery. Linear regression analyses were used to find potential determinants associated with an LV function and geometry change. Results After BS, body mass index decreased (39.7 ± 8.0 kg/m 2 to 28.4 ± 6.4 kg/m 2 , P < 0.001). Systolic blood pressure and diastolic blood pressure decreased (152.0 ± 19.9 mmHg to 116.5 ± 13.6 mmHg, P < 0.001, and 94.1 ± 12.6 mmHg to 76.8 ± 12.2 mmHg, P < 0.001, respectively). Left ventricular mass index (LVMI) decreased (43.7 ± 16.4 g/m 2.7 to 37.8 ± 13.4 g/m 2.7 , P < 0.001). The change in LVMI was correlated with the change in BMI (R 2 = 0.14, P < 0.001). 10-year and lifetime ASCVD risk decreased [3.7% (1.0-11.2) to 0.2% (0.1–0.8), P < 0.001, and 44.2% (34.5–56.9) to 10.7% (9.0-13.7), P < 0.001, respectively].
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Wang et al. (2022) conducted a cohort in Obesity (n=143). Bariatric surgery (LRYGB or LSG) vs. Preoperative baseline was evaluated on Left ventricular mass index (LVMI) in g/m2.7 (p=<0.001). Bariatric surgery significantly reduced left ventricular mass index from 43.7 to 37.8 g/m2.7 and decreased 10-year ASCVD risk from 3.7% to 0.2% in Chinese patients with obesity.
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