What question did this study set out to answer?

To evaluate VISTA's role in cancer immunotherapy and its impact on patient selection for anti-VISTA therapies.

February 20, 2023Frontiers in ImmunologyOpen Access

VISTA expression and patient selection for immune-based anticancer therapy

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Review explores VISTA roles in tumors, supporting patient selection for immune therapy, suggesting meaningful implications.

To evaluate VISTA's role in cancer immunotherapy and its impact on patient selection for anti-VISTA therapies.
Reviewed literature on VISTA expression across various malignancies.
Correlated VISTA expression patterns with known immunotherapy biomarkers.
Analyzed interactions of VISTA with other checkpoint molecules in the tumor microenvironment.
Identified mechanisms by which VISTA influences T cell quiescence and myeloid cell populations.
Outlined distinct patterns of VISTA expression related to tumor-infiltrating lymphocytes and PD-L1.
Proposed strategies for patient selection to enhance efficacy of VISTA-targeted therapies.

Martin et al. (2023) studied this question.

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