Prothrombin activation by the complete prothrombin activation system (Factor Xa, Factor Va, phospholipid, and Ca2+) can occur via the same two-step mechanism previously demonstrated with only Factor Xa, phospholipid, and Ca2+ (Esmon, C. T., Owen, W. G., and Jackson, C. M. (1974) J. Biol. Chem. 249, 7798–7807). [see PDF for equation] Both Intermediate 2 and Fragment 1·2 are required for the activation intermediate to meet necessary kinetic conditions.
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Esmon et al. (1974) studied this question.
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