Key result
The kallikrein-kinin system plays an important role in regulating cardiovascular and renal function and mediates many beneficial effects of ACE inhibitors and ARBs on target organ damage.
Design
Review
Authors
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Supports KKS mediation of ACEi/ARB benefits; hypothesis-generating for direct modulators, with no practice change warranted.
The kallikrein-kinin system is a critical regulator of cardiovascular and renal function and mediates many of the protective effects of ACE inhibitors and ARBs.
Rhaleb et al. (2011) conducted a review in Hypertension and cardiovascular/renal function. The kallikrein-kinin system plays an important role in regulating cardiovascular and renal function and mediates many beneficial effects of ACE inhibitors and ARBs on target organ damage.
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