Key result
Interspecies electrophysiology differences hinder translation of preclinical arrhythmia models to human therapies.
Population
Animal models (mouse, rat, guinea pig, rabbit, dog) and human ventricular cardiomyocytes
Design
Review
Authors
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Clinicians should interpret rodent arrhythmia models cautiously; leaves open whether mathematical modeling can reliably improve human translation.
Understanding species-specific differences in cardiac electrophysiology is critical for improving the translation of preclinical arrhythmia models to human therapies.
Edwards et al. (2017) conducted a review in Cardiac Arrhythmia. Interspecies differences in cardiomyocyte electrophysiology, particularly in repolarizing potassium currents and calcium handling, complicate the translation of preclinical arrhythmia models to human therapies.
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