Key result
Circadian timing influenced the ventilatory response to suprathreshold carbon dioxide, exhibiting a rhythm amplitude of approximately 25% mediated by variations in the CO2 threshold.
Why the study?
Do healthy subjects exhibit circadian rhythms in respiratory chemoreflex responses independent of arousal state and metabolic rate?
Population
10 healthy male subjects
Follow-up
36 h
Authors
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May heighten nocturnal respiratory instability risk; leaves open relevance to sleep-disordered breathing or HF.
Observational (n=10)
Do healthy subjects exhibit circadian rhythms in respiratory chemoreflex responses independent of arousal state and metabolic rate?
Circadian rhythms in lung ventilation are driven by variations in the chemoreflex threshold rather than arousal or metabolic rate, which may increase the propensity for respiratory instability at night.
Stephenson et al. (2000) conducted an observational in Healthy (n=10). Constant routine protocol was evaluated on Respiratory chemoreflex responses and lung ventilation. Circadian timing influenced the ventilatory response to suprathreshold carbon dioxide, exhibiting a rhythm amplitude of approximately 25% mediated by variations in the CO2 threshold.
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