Platelet P2Y ₁₂ Blockers Confer Direct Postconditioning-Like Protection in Reperfused Rabbit Hearts
Key result
Cangrelor administered shortly before reperfusion reduced infarction from 38% of the ischemic zone in control hearts to 19% in a rabbit model of ischemia/reperfusion.
Why the study?
Do P2Y12 blockers like cangrelor and clopidogrel reduce infarction size in a rabbit model of ischemia/reperfusion?
Population
Rabbit model of ischemia/reperfusion caused by reversible ligation of a coronary artery
Comparison
P2Y12 receptor blockers vs Control hearts, ischemic postconditioning…
Design
Preclinical
Follow-up
3 hours of reperfusion
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for P2Y12 inhibition in reperfusion injury; leaves open translation to clinical practice.
Structured PICO
Do P2Y12 blockers like cangrelor and clopidogrel reduce infarction size in a rabbit model of ischemia/reperfusion?
P
Population
Rabbit model of ischemia/reperfusion caused by reversible ligation of a coronary artery (30-minute regional ischemia/3-hour reperfusion)
I
Intervention
P2Y12 receptor blockers (cangrelor administered shortly before reperfusion, or clopidogrel requiring 2 days of treatment)
C
Comparator
Control hearts, ischemic postconditioning (IPOC), aspirin, or heparin
O
Outcome
Infarction size as a percentage of the ischemic zonesurrogate
Main Result
Absolute Event Rate: 19% vs 38%
P2Y12 inhibitors cangrelor and clopidogrel protect rabbit hearts against infarction via signal transduction during reperfusion, mimicking ischemic postconditioning.
Cite This Study
Yang et al. (2012) studied Ischemia/reperfusion injury (myocardial infarction). Cangrelor and Clopidogrel vs. Control was evaluated on Infarction size (% of ischemic zone). Cangrelor administered shortly before reperfusion reduced infarction from 38% of the ischemic zone in control hearts to 19% in a rabbit model of ischemia/reperfusion.