Key result
T*2 mapping and diffusion-weighted MRI yield almost equivalent information on myocardial fiber structure in the isolated rat heart.
Why the study?
Does T*2-weighted MRI provide equivalent information on myocardial fiber structure compared to diffusion-weighted MRI in isolated rat hearts?
Does T*2-weighted MRI provide equivalent information on myocardial fiber structure compared to diffusion-weighted MRI in isolated rat hearts?
T*2 mapping provides equivalent information to diffusion-weighted MRI for visualizing myocardial fiber structure in isolated rat hearts.
T*2 mapping may simplify preclinical fiber imaging in rat models; leaves open validation for human cardiac MRI.
Myocardial fiber structure can be determined with diffusion-weighted (DW) MRI as well as with high-resolution T*(2) imaging. The purpose of the present study was twofold: to provide a more quantitative description of T*(2)-based myocardial fiber contrast, and to compare the T*(2)-based fiber structure with high-resolution (78 microm in-plane, 1-mm slice thickness) DW images of the isolated rat heart at 11.75 T. This study demonstrates that the static dephasing regime is responsible for visualization of myocardial microstructure, and that the dynamic dephasing regime can be neglected. In comparison with DW experiments, T*(2) mapping and DW images yield almost equivalent information on myocardial fiber structure.
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Köhler et al. (2003) studied Myocardial fiber structure. T*2-weighted MRI vs. Diffusion-weighted (DW) MRI was evaluated on Myocardial fiber structure visualization. T*2 mapping and diffusion-weighted MRI yield almost equivalent information on myocardial fiber structure in the isolated rat heart.
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