Key result
Early-diastolic load (β=6.9, P<0.0001), restoring forces (β=-11.3, P<0.0001), and relaxation rate (β=-1.6, P<0.003) are independent determinants of peak left ventricular untwisting rate.
Why the study?
Are early-diastolic load, restoring forces, and relaxation rate independent determinants of left ventricular untwisting rate in an animal model?
Population
10 anesthetized dogs
Comparison
Varying LV preloads, increased contractility… vs Baseline conditions
Design
Preclinical
Authors
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Provides mechanistic insight into LV untwisting in animals; leaves open translation to human diastolic assessment.
Are early-diastolic load, restoring forces, and relaxation rate independent determinants of left ventricular untwisting rate in an animal model?
Effect estimate: β=6.9
p-value: p=<0.0001
Early-diastolic load, restoring forces, and relaxation rate are independent determinants of peak left ventricular untwisting rate, providing mechanistic insight into its use as a marker of diastolic function.
Opdahl et al. (2012) studied Left ventricular diastolic function (n=10). Varying LV preloads, increased contractility, and myocardial ischemia was evaluated on Peak left ventricular untwisting rate (UTR) (β=6.9, p=<0.0001). Early-diastolic load (β=6.9, P<0.0001), restoring forces (β=-11.3, P<0.0001), and relaxation rate (β=-1.6, P<0.003) are independent determinants of peak left ventricular untwisting rate.
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