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Factor analysis of responses from 1002 men and women were used to define two subscales of the Cook and Medley Hostility Scale. Both the Cynicism and the Paranoid Alienation subscale described attitudes of mistrust and alienation, and both were correlated with MMPI factors measuring aspects of psychopathology. It was suggested that measures of the broader domain of Agreeableness-Antagonism be examined as possible predictors of CHD.
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Costa et al. (1986) studied this question.
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