Key result
Elevated atherogenic index of plasma and BMI ≥24 are associated with ~79% higher CVD risk.
Why the study?
The atherogenic index of plasma (AIP) predicts cardiovascular disease, but whether body mass index (BMI) mediates this relationship was unclear.
Does elevated atherogenic index of plasma and body mass index increase the risk of cardiovascular diseases in middle-aged and older Chinese adults?
Cohort (n=5,468)
Yes
Does elevated atherogenic index of plasma and body mass index increase the risk of cardiovascular diseases in middle-aged and older Chinese adults?
Effect estimate: HR 1.789 (95% CI 1.491-2.147)
Absolute Event Rate: 28.6% vs 17.3%
p-value: p=<0.001
Elevated atherogenic index of plasma and body mass index jointly increase the risk of cardiovascular diseases in middle-aged and older Chinese adults, with BMI mediating approximately 30% of the AIP-related risk.
Background: Evidence has emerged that suggests the atherogenic index of plasma (AIP), as determined by blood lipid levels, is a valuable predictor of the onset of cardiovascular diseases. The correlation between AIP and cardiovascular diseases may be facilitated by body mass index (BMI), as atherosclerosis is prevalent in overweight and obese populations. In order to assess the combined predictive value of the AIP and BMI in predicting outcomes associated with cardiovascular diseases, this study sought to determine if BMI mediates the relationship between the AIP and cardiovascular disease risk. Methods: Participants in this study were those who were without cardiovascular diseases at baseline and were members of the China Health and Retirement Longitudinal Study (CHARLS). We performed adjusted regression analysis and mediation. AIP was calculated using the logarithm of the ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C). The estimated body weight and height were used to calculate the BMI. Results: This study included 5468 participants. Cardiovascular diseases were highly linked with both BMI and AIP. In contrast to those with a lower AIP (median level) and BMI <24, those with an elevated AIP and increased BMI presented a higher risk for developing cardiovascular conditions (HR: 1.789; 95% CI: 1.491-2.147). Additionally, about 30.57% of the connection between AIP and cardiovascular diseases was strongly mediated by BMI. Conclusions: Among Chinese adults in their middle and advanced years, the AIP and BMI jointly have been associated to a higher risk of cardiovascular diseases, and BMI could serve as a mediator in this connection.
No takes yet. Share an insight, caveat, or question.
Xu et al. (2025) conducted a cohort in Cardiovascular diseases (n=5,468). Elevated Atherogenic Index of Plasma (AIP ≥ median) and Body Mass Index (BMI ≥ 24) vs. AIP < median and BMI < 24 was evaluated on Occurrence of cardiovascular diseases (heart disease or stroke) (HR 1.789, 95% CI 1.491-2.147, p=<0.001). Elevated atherogenic index of plasma combined with a body mass index ≥24 increased the risk of cardiovascular diseases (HR 1.789), with BMI mediating 30.57% of this relationship.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: