Key result
Higher atherogenic index of plasma (per 0.1 unit increase) was independently associated with an increased risk of obstructive coronary plaque (OR 1.079) beyond traditional risk factors.
Why the study?
Atherogenic index of plasma is suggested as a novel marker for atherosclerosis, but its utility for identifying advanced subclinical CAD in subjects without overt renal dysfunction needed evaluation.
Does a higher atherogenic index of plasma predict advanced subclinical coronary artery disease in adults without overt renal dysfunction?
Cohort (n=6,928)
No
Does a higher atherogenic index of plasma predict advanced subclinical coronary artery disease in adults without overt renal dysfunction?
The atherogenic index of plasma is independently associated with advanced subclinical coronary artery disease, suggesting its utility as a predictive marker for coronary atherosclerosis beyond traditional risk factors.
AIP may enhance subclinical CAD risk stratification beyond traditional factors; hypothesis-generating and requires prospective validation before clinical use.
BACKGROUND: Atherogenic lipoprotein profile of plasma is an important risk factor for atherosclerosis. The atherogenic index of plasma (AIP) has been suggested as a novel marker for atherosclerosis. HYPOTHESIS: AIP is a useful marker of advanced subclinical coronary artery disease (CAD) in subjects without overt renal dysfunction. METHODS: evaluated by coronary computed tomography angiography (CCTA) for health check-up were included. The relation of AIP to advanced CAD (heavy coronary calcification, defined as coronary artery calcium score [CACS] >100 or obstructive coronary plaque [OCP], defined as plaque with >50% stenosis) was evaluated. RESULTS: All participants were stratified into four groups based on AIP quartiles. The prevalence of CACS >100 (group I [lowest] 4.7% vs group II 7.0% vs group III 8.8% vs group IV 10.0%) and OCP (group I 3.7% vs group II 6.4% vs group III 8.8% vs group IV 10.9%) (all P < .001) increased with elevating AIP quartiles. Higher AIP (per 0.1 unit increase) was associated with an increased risk of CACS >100 (odds ratio [OR] 1.057, 95% confidence interval (CI) 1.010 to 1.106, P = .017; relative risk (RR) 1.048, 95% CI 1.009-1.089, and P = .015) and OCP (OR 1.079, 95% CI 1.033-1.127, P = .001; RR 1.069, 95% CI 1.031-1.108, P < .001) after adjusting for age > 60 years, male sex, hypertension, diabetes mellitus, dyslipidaemia, obesity, and proteinuria. CONCLUSION: AIP is independently associated with advanced subclinical CAD beyond traditional risk factors.
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Won et al. (2020) conducted a cohort in Subclinical coronary artery disease (n=6,928). Atherogenic index of plasma (AIP) vs. Lower AIP levels was evaluated on Obstructive coronary plaque (OCP) (OR 1.079, 95% CI 1.033-1.127, p=0.001). Higher atherogenic index of plasma (per 0.1 unit increase) was independently associated with an increased risk of obstructive coronary plaque (OR 1.079) beyond traditional risk factors.
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