Why the study?
Does the addition of antioxidant and reparant therapy (sodium bicarbonate, coenzyme Q10, solcoseryl) to standard antiarrhythmic therapy improve the restoration and maintenance of sinus rhythm in patients with new-onset paroxysmal atrial fibrillation or flutter?
RCT (n=53)
Open-label
Random numbers
No
Does the addition of antioxidant and reparant therapy (sodium bicarbonate, coenzyme Q10, solcoseryl) to standard antiarrhythmic therapy improve the restoration and maintenance of sinus rhythm in patients with new-onset paroxysmal atrial fibrillation or flutter?
Absolute Event Rate: 0% vs 28%
p-value: p=<0.05
The addition of antioxidant and reparant therapy to standard antiarrhythmic drugs significantly improved the restoration and maintenance of sinus rhythm at 1 month in patients with paroxysmal atrial fibrillation.
Addition of antioxidants and reparants to amiodarone improves early sinus rhythm maintenance in paroxysmal AF; extends RCT evidence for adjunctive metabolic therapy.
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Хабчабов et al. (2016) conducted an RCT in Paroxysmal atrial fibrillation or atrial flutter (n=53). Cordarone with antioxidants (sodium bicarbonate, kudesan) and reparant (solcoseryl) vs. Cordarone and Dabigatran without antioxidant therapy and reparant was evaluated on Presence of atrial fibrillation paroxysms at 1 month (p=<0.05).
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