Key result
Second order highpass spatial filtering with 0.2 mm electrode spacing achieved optimal separation of local and distant wavefronts in epicardial electrograms from canine infarcts.
Second order highpass spatial filtering with 0.2 mm electrode spacing optimally separates local and distant wavefronts in epicardial electrograms from infarct regions in vitro.
Optimizes wavefront separation in canine infarct models; leaves open translation to clinical electroanatomic mapping.
Epicardial electrograms from infarct regions have multiple deflections due to the superposition of different activation wavefronts. This study aims to separate local and distant wavefronts by two-dimensional spatial highpass filtering. For that purpose, extracellular electrograms were recorded from thin (<1 mm) epicardial slices from 1-day-old canine infarcts, isolated in a superfused tissue bath and stimulated at twice threshold. Two-dimensional filter algorithms were generated for orthogonal electrode arrangements with center-to-center distances from 1 mm to 0.01 mm. Optimal separation was achieved by second order highpass spatial filtering with 0.2 mm electrode spacing. In all tested algorithms the filter performance was degraded when the distance between the recording electrodes and the tissue was greater than the inter-electrode distance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">></ETX>
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Romberg et al. (2002) studied Myocardial infarction (canine model). Two-dimensional spatial highpass filtering was evaluated on Separation of local and distant wavefronts. Second order highpass spatial filtering with 0.2 mm electrode spacing achieved optimal separation of local and distant wavefronts in epicardial electrograms from canine infarcts.
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