Key result
The bidomain model successfully explains complex cardiac pacing phenomena, including virtual electrodes, make and break excitation mechanisms, and the dip in the anodal strength-interval curve.
The bidomain model provides a theoretical framework that successfully explains complex cardiac pacing phenomena, including virtual electrodes and the mechanisms of make and break excitation.
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Strengthens bidomain modeling for pacing research; leaves open prospective clinical validation before practice change.
The last two decades have produced significant advances in our theoretical understanding of cardiac pacing. The bidomain model, a mathematical representation of the anisotropic electrical properties of cardiac tissue, has provided insight into many long-standing mysteries of pacing, such as the mechanisms of make and break excitation, the shape of the strength-interval curve, and the induction of reentry by burst pacing. This paper reviews the application of the bidomain model to these and other topics, and summarizes our theoretical understanding of how electrical excitation of the heart works.
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Bradley J. Roth (2011) conducted a review in Cardiac pacing and excitation. Bidomain model simulations was evaluated. The bidomain model successfully explains complex cardiac pacing phenomena, including virtual electrodes, make and break excitation mechanisms, and the dip in the anodal strength-interval curve.
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