Population
Computational model of the human cardiopulmonary system
Comparison
Simulation of the Valsalva maneuver vs Nominal baseline data
Design
Preclinical
Authors
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Validates integrated cardio-pulmonary modeling for Valsalva; extends prior decoupled approaches yet leaves open human translation.
A novel computational model successfully integrates cardiovascular and pulmonary dynamics to accurately simulate hemodynamic responses during the Valsalva maneuver.
Lu et al. (2001) studied this question.
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