Key result
Cardiac fibroblasts undergo functional and electrophysiological changes during activation that may directly modulate the arrhythmic substrate in diseased hearts.
Design
Review
Authors
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Does not support changing arrhythmia management; hypothesis-generating for fibroblast-targeted therapies pending clinical validation.
This review highlights the direct role of cardiac fibroblasts in modulating the electrophysiological substrate, suggesting new therapeutic targets for preventing arrhythmias associated with cardiac fibrosis.
Vásquez et al. (2011) conducted a review in Cardiac fibrosis and arrhythmias. Cardiac fibroblasts undergo functional and electrophysiological changes during activation that may directly modulate the arrhythmic substrate in diseased hearts.
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