Incidence and characteristics of phrenic nerve palsy following pulmonary vein isolation with the second-generation as compared with the first-generation cryoballoon in 360 consecutive patients
Key result
The second-generation cryoballoon for pulmonary vein isolation resulted in a 2.8% rate of persistent phrenic nerve palsy compared to 1.9% with the first-generation balloon (P=0.63).
Why the study?
Does the second-generation cryoballoon alter the incidence and characteristics of phrenic nerve palsy compared to the first-generation cryoballoon in patients undergoing pulmonary vein isolation for atrial fibrillation?
Population
360 consecutive patients with atrial fibrillation undergoing pulmonary vein isolation
Comparison
Second-generation cryoballoon for pulmonary vein… vs First-generation cryoballoon for pulmonary vein…
Design
Cohort
Follow-up
Up to complete recovery of phrenic nerve function
Authors
Discussion
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Member takes
Implication
No difference in persistent phrenic nerve palsy rates; leaves open clinical relevance of longer recovery with second-generation devices.
Study Design
Type
Observational (n=360)
Structured PICO
Does the second-generation cryoballoon alter the incidence and characteristics of phrenic nerve palsy compared to the first-generation cryoballoon in patients undergoing pulmonary vein isolation for atrial fibrillation?
P
Population
360 consecutive patients with atrial fibrillation undergoing pulmonary vein isolation
I
Intervention
Second-generation cryoballoon (CB2) for pulmonary vein isolation
C
Comparator
First-generation cryoballoon (CB1) for pulmonary vein isolation
O
Outcome
Incidence and characteristics of phrenic nerve palsy (PNP) (persistent and transient)safety
Main Result
Absolute Event Rate: 2.8% vs 1.9%
p-value: p=0.63
While the incidence of phrenic nerve palsy is similar between first- and second-generation cryoballoons, the second-generation device is associated with a significantly longer time to nerve function recovery.
Cite This Study
Fürnkranz et al. (2015) conducted an observational in Atrial fibrillation (n=360). Second-generation cryoballoon (CB2) vs. First-generation cryoballoon (CB1) was evaluated on Persistent phrenic nerve palsy (present at discharge) (p=0.63). The second-generation cryoballoon for pulmonary vein isolation resulted in a 2.8% rate of persistent phrenic nerve palsy compared to 1.9% with the first-generation balloon (P=0.63).