Key result
RNA-Seq analysis following Ang II infusion identified 1,801 differentially expressed genes at 1, 3, and 7 days, highlighting ubiquitin C as a key factor in hypertension-induced cardiac injury.
RNA-Seq analysis identified 1,801 differentially expressed genes and highlighted ubiquitin C as a potentially key player in the molecular mechanism of hypertension-induced cardiac injury.
BACKGROUND/AIMS: Hypertension plays a critical role in the cardiac inflammation and injury. However, the mechanism of how hypertension causes the cardiac injury at a molecular level remains to be elucidated. METHODS: RNA-Seq has been demonstrated to be an effective approach for transcriptome analysis, which is essential to reveal the molecular constituents of cells and tissues. In this study, we investigated the global molecular events associated with the mechanism of hypertension induced cardiac injury using RNA-Seq analysis. RESULTS: Our results showed that totally 1,801 genes with different expression variations were identified after Ang II infusion at 1, 3 and 7 days. Go analysis showed that the top 5 high enrichment Go terms were response to stress, response to wounding, cellular component organization, cell activation and defense response. KEGG pathway analysis revealed the top 5 significantly overrepresented pathways were associated with ECM-receptor interaction, focal adhesion, protein digestion and absorption, phagosome and asthma. Moreover, protein-protein interaction network analysis indicated that ubiquitin C may play a key role in the processes of hypertension-induced cardiac injury. CONCLUSION: Our study provides a comprehensive understanding of the transcriptome events in hypertension-induced cardiac pathology.
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Li et al. (2016) studied Hypertension-induced cardiac injury. Ang II infusion was evaluated on Differentially expressed genes. RNA-Seq analysis following Ang II infusion identified 1,801 differentially expressed genes at 1, 3, and 7 days, highlighting ubiquitin C as a key factor in hypertension-induced cardiac injury.
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