What does this research mean for the field?

PMA and ANP desensitization of the atrial natriuretic peptide receptor (GC-A) are distinct events mediated by dephosphorylation of specific residues through PKC-dependent and -independent pathways, respectively, contradicting previous suggestions that PKC phosphorylates the receptor. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

May 1, 1994Journal of Biological ChemistryOpen Access

Protein kinase C-dependent desensitization of the atrial natriuretic peptide receptor is mediated by dephosphorylation.

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Population

Stable GC-A transfectants of NIH3T3 cells

Design

Preclinical

Authors

LPLincoln R. PotterUniversity of Minnesota System DGDavid L. GarbersThe University of Texas at Austin

Discussion

Member takes

Implication

No immediate clinical implications for ANP signaling; challenges prior PKC phosphorylation model of GC-A desensitization in animals.

Structured PICO

Population

Stable GC-A transfectants of NIH3T3 cells

Intervention

Incubation with atrial natriuretic peptide (ANP) or phorbol 12-myristate 13-acetate (PMA), with or without specific PKC inhibitor GF-109203X

Outcome

Hormone-dependent cGMP elevations, guanylyl cyclase activity, and receptor phosphorylation statussurrogate

Desensitization of the atrial natriuretic peptide receptor by PMA and ANP is mediated by distinct dephosphorylation events rather than phosphorylation.

Cite This Study

Potter et al. (1994) studied this question.

synapsesocial.com/papers/6a1ca87f5a7763abe7899222 https://doi.org/10.1016/s0021-9258(17)36672-3

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Protein kinase C-dependent desensitization of the atrial natriuretic peptide receptor is mediated by dephosphorylation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Protein kinase C-dependent desensitization of the atrial natriuretic peptide receptor is mediated by dephosphorylation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider