Key result
Higher apoB/apoA-I ratio is linked to nearly doubled AS hemodynamic progression rate, driven by younger patients.
Why the study?
Does a higher apoB/apoA-I ratio predict faster hemodynamic progression of aortic stenosis in patients with at least mild AS?
Cohort (n=159)
No
Does a higher apoB/apoA-I ratio predict faster hemodynamic progression of aortic stenosis in patients with at least mild AS?
Absolute Event Rate: 0.3% vs 0.16%
p-value: p=0.02
A higher apoB/apoA-I ratio is significantly associated with faster hemodynamic progression of aortic stenosis in patients younger than 70 years, suggesting atherogenic lipoproteins play a role in early/middle-aged AS progression.
No takes yet. Share an insight, caveat, or question.
May support closer surveillance in younger AS patients; leaves open whether apoB/apoA-I ratio identifies modifiable progression risk.
Tastet et al. (2018) conducted a cohort in Aortic Stenosis (n=159). Top tertile of apoB/apoA-I ratio (≥0.62) vs. Bottom and middle tertiles of apoB/apoA-I ratio (<0.62) was evaluated on Hemodynamic progression rate of AS measured as the change in peak aortic jet velocity (V peak) (p=0.02). Higher apoB/apoA-I ratio was significantly associated with faster hemodynamic progression of aortic stenosis (0.30 vs 0.16 m/s, P=0.02), an effect driven primarily by patients under 70 years of age.
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