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This research aims to characterize the antigen receptor on T cells and its interaction with specific monoclonal antibodies.

The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody.

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This research aims to characterize the antigen receptor on T cells and its interaction with specific monoclonal antibodies.
Prepared B cell hybridoma KJ1-26.1 from mice immunized with T cell hybridoma DO-11.10.
Tested binding of KJ1-26.1 to various T cell hybridomas and assessed I-restricted antigen recognition.
Analyzed protein characteristics including molecular weight and binding properties.
KJ1-26.1 blocks I-restricted recognition by DO-11.10 and its specific subclone DO-11.10.24.
KJ1-26.1 binds to approximately 15,000 receptor molecules per cell on DO-11.10.
The antibody precipitates an 80,000 dimer, suggesting distinct receptor characteristics.

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Randomized trial demonstrates distinct binding of monoclonal antibody to T cell receptors, suggesting specificity in recognition of antigens.

Haskins et al. (1983) studied this question.

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Randomized trial demonstrates distinct binding of monoclonal antibody to T cell receptors, suggesting specificity in recognition of antigens.