What does this research mean for the field?

In Caenorhabditis elegans, the Ro60 homologue ROP-1 is required to maintain normal levels of its associated Y RNA (CeY RNA), but it is not essential for viability or normal development under standard laboratory conditions. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

January 1, 1999GeneticsOpen Access

The Levels of the RoRNP-Associated Y RNA Are Dependent Upon the Presence of ROP-1, the Caenorhabditis elegans Ro60 Protein

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Population

Caenorhabditis elegans strain in which rop-1 has been disrupted

Design

Preclinical

Authors

JLJean‐Claude LabbéInstitute for Research in Immunology and Cancer SHSiegfried HekimiMcGill University LRLuis A. RokeachUniversité Libre de Bruxelles

Discussion

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Implication

No immediate clinical implications from C. elegans data; extends RoRNP functional understanding while leaving vertebrate roles open.

Structured PICO

Population

Caenorhabditis elegans strain in which rop-1 has been disrupted

Intervention

Disruption of rop-1 gene and transgenic expression of wild-type rop-1

Outcome

Phenotypic characterization and levels of ROP-1-associated RNA (CeY RNA)surrogate

The ROP-1 protein is required for maintaining levels of CeY RNA in C. elegans, though it does not play a crucial role for survival under laboratory culture conditions.

Cite This Study

Labbé et al. (1999) studied this question.

synapsesocial.com/papers/6a1cb622c9d372840a899e8d https://doi.org/10.1093/genetics/151.1.143

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The Levels of the RoRNP-Associated Y RNA Are Dependent Upon the Presence of ROP-1, the Caenorhabditis elegans Ro60 Protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Levels of the RoRNP-Associated Y RNA Are Dependent Upon the Presence of ROP-1, the Caenorhabditis elegans Ro60 Protein

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

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